MR Spectroscopy of the Human Prostate Using Surface Coil at 3 T: Metabolite Ratios, Age-Dependent Effects, and Diagnostic Possibilities

作者：Weis Jan^*; Jorulf Hakan; Bergman Antonina; Ortiz Nieto Francisco; Haggman Michael; Ahlstrom Hakan

来源：Journal of Magnetic Resonance Imaging, 2011, 34(6): 1277-1284.

DOI：10.1002/jmri.22746

• single-voxel spectroscopy
• spectroscopic imaging
• prostate cancer
• 3 Tesla
• LCModel
• surface coil

Purpose: To measure prostate spectra of healthy volunteers using a surface coil, to demonstrate age-dependent effects, and to investigate diagnostic possibilities for prostate cancer detection.
Materials and Methods: Single-voxel and 2D magnetic resonance spectroscopic imaging (MRSI) spectra of 51 healthy volunteers with biopsy-proven prostate carcinoma of 20 patients for comparison were measured and processed using the LCModel. The mean normalized spectra and mean metabolite-to-citrate intensity ratios were computed.
Results: Metabolite-to-citrate ratios of healthy volunteers were lower in the older group (>51 years) than in the younger group (<45 years). The peripheral zone (PZ) revealed a lower metabolite-to-citrate intensity ratio than the central gland (CG). Age-related differences in metabolite-to-citrate ratio were insignificant in the voxels with predominantly CG tissue, whereas significant differences were found in the PZ. Sensitivity in detecting prostate cancer by single-voxel spectroscopy (SVS) and 2D MRSI was 75% and 80%, respectively.
Conclusion: SVS and 2D MRSI of the prostate at 3 T, using a surface coil, are useful in situations when insertion of the endorectal coil into the rectum is difficult or impossible. Our findings of age-dependent effects may be of importance for the analysis of patient spectra.

• 出版日期2011-12