An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone

作者：Tyrikos Ergas Theodore; Giannopoulos Vasileios; Smonou Ioulia^*

来源：Molecules, 2018, 23(3): 640.

DOI：10.3390/molecules23030640

• chemoenzymatic
• alpha-pyrone
• ketoreductase
• bioreduction
• rugulactone
• inhibitor

Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor kappa B (NF-kappa B) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail.

• 出版日期2018-3