Differential Prevalence of Transporter Polymorphisms in Symptomatic and Asymptomatic Falciparum Malaria Infections in Uganda

作者：Tukwasibwe Stephen; Mugenyi Levi; Mbogo George W; Nankoberanyi Sheila; Maiteki Sebuguzi Catherine; Joloba Moses L; Nsobya Samuel L; Staedke Sarah G; Rosenthal Philip J^*

来源：Journal of Infectious Diseases, 2014, 210(1): 154-157.

DOI：10.1093/infdis/jiu044

• fitness
• malaria
• Plasmodium
• polymorphism
• virulence

We explored associations between Plasmodium falciparum drug resistance-mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design. All 243 febrile children (cases) and 243 randomly selected asymptomatic children (controls) were included. In a multivariate analysis adjusting for age, complexity of infection, and parasite density, the prevalence of wild-type genotypes was significantly higher in febrile children compared to asymptomatic children (pfcrt K76T: odds ratio [OR] 4.41 [95% confidence interval {CI}, 1.28-15.1]; pfmdr1 N86Y: OR 4.08 [95% CI, 2.01-8.31], and pfmdr1 D1246Y: OR 4.90 [95% CI, 1.52-15.8]), suggesting greater virulence for wild-type parasites.

• 出版日期2014-7-1