Uterine Glomeruloid Hemangioma in a Patient Without POEMS Syndrome

作者：Giner Francisco; Compan Amparo; Monteagudo Carlos^*

来源：International Journal of Surgical Pathology, 2012, 20(4): 407-410.

DOI：10.1177/1066896911429297

• glomeruloid hemangioma
• POEMS syndrome
• myometrial vascular lesion
• vascular epithelial growth factor (VEGF)
• uterine tumor

Cutaneous glomeruloid hemangioma is a hallmark of POEMS syndrome. These patients have elevated serum levels of vascular endothelial growth factor. The authors report an extracutaneous uterine glomeruloid hemangioma in an 82-year-old woman with a history of breast and endometrial carcinomas. Within the lumen of myometrial vessels, a lobular, glomeruloid proliferation of capillary-like CD31 and vascular endothelial growth factor receptor-1-positive endothelial cells was found. The capillary loops were lined by endothelial cells, most of them containing PAS-positive and immunoglobulin-positive eosinophilic hyaline globules (thanatosomes). This vascular proliferation was consistent with a glomeruloid hemangioma. Although an extracutaneous glomeruloid vascular proliferation has been found in the retroperitoneal adipose tissue in a patient with POEMS syndrome, this study reports what seems to be the first case of visceral glomeruloid hemangioma in a patient without POEMS syndrome. The authors hypothesize that the glomeruloid endothelial cell proliferation with vascular endothelial growth factor receptor-1 expression may be a paraneoplastic phenomenon.

• 出版日期2012-8