APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds

作者：Lyall Donald M; Maniega Susana Munoz; Harris Sarah E; Bastin Mark E; Murray Catherine; Lutz Michael W; Saunders Ann M; Roses Allen D; Hernandez Maria del C Valdes; Royle Natalie A; Starr John M; Porteous David J; Deary Ian J; Wardlaw Joanna M^*

来源：International Journal of Stroke, 2015, 10(8): 1297-1300.

DOI：10.1111/ijs.12615

• brain microbleeds
• epidemiology
• MRI
• neurology
• risk factors
• vascular events

Background Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease.
Aim and/or hypothesis To test for independent associations between two Alzheimer's disease-susceptibility gene loci APOE epsilon and the TOMM40 '523' poly-T repeat - and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults.
Methods Participants in the Lothian Birth Cohort 1936 underwent genotyping for APOE e and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72.70 years (standard deviation = 0.7; range = 71-74).
Results No significant effects of APOE epsilon or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants.
Conclusions Lack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.

• 出版日期2015-12