Near-infrared spectroscopy assessment of cerebral oxygen metabolism in the developing premature brain

作者：Roche Labarbe Nadege^*; Fenoglio Angela; Aggarwal Alpna; Dehaes Mathieu; Carp Stefan A; Franceschini Maria Angela; Grant Patricia Ellen

来源：Journal of Cerebral Blood Flow and Metabolism, 2012, 32(3): 481-488.

DOI：10.1038/jcbfm.2011.145

• brain hemodynamic development
• cerebral oxygen consumption
• diffuse correlation spectroscopy
• frequency-domain near-infrared spectroscopy
• premature neonates

Little is known about cerebral blood flow, cerebral blood volume (CBV), oxygenation, and oxygen consumption in the premature newborn brain. We combined quantitative frequency-domain near-infrared spectroscopy measures of cerebral hemoglobin oxygenation (SO2) and CBV with diffusion correlation spectroscopy measures of cerebral blood flow index (BFix) to determine the relationship between these measures, gestational age at birth (GA), and chronological age. We followed 56 neonates of various GA once a week during their hospital stay. We provide absolute values of SO2 and CBV, relative values of BFix, and relative cerebral metabolic rate of oxygen (rCMRO(2)) as a function of postmenstrual age (PMA) and chronological age for four GA groups. SO2 correlates with chronological age (r = -0.54, P value <= 0.001) but not with PMA (r = -0.07), whereas BFix and rCMRO(2) correlate better with PMA (r = 0.37 and 0.43, respectively, P value <= 0.001). Relative CMRO2 during the first month of life is lower when GA is lower. Blood flow index and rCMRO(2) are more accurate biomarkers of the brain development than SO2 in the premature newborns. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 481-488; doi: 10.1038/jcbfm.2011.145; published online 26 October 2011

• 出版日期2012-3