A perspective on the developmental toxicity of inhaled nanoparticles

作者：Hougaard Karin Sorig^*; Campagnolo Luisa; Chavatte Palmer Pascale; Tarrade Anne; Rousseau Ralliard Delphine; Valentino Sarah; Park Margriet V D Z; de Jong Wim H; Wolterink Gerrit; Piersma Aldert H; Ross Bryony L; Hutchison Gary R; Hansen Jitka Stilund; Vogel Ulla; Jackson Petra; Slama Remy; Pietroiusti Antonio; Cassee Flemming R

来源：Reproductive Toxicology, 2015, 56: 118-140.

DOI：10.1016/j.reprotox.2015.05.015

• Nanoparticles
• Nanomaterial
• Ultrafine particles
• Developmental toxicity
• Reproductive toxicity
• Inhalation
• Instillation
• Pregnancy

This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.

• 出版日期2015-8-15