Additive Effect of Combined Application of Magnesium and MK-801 on Analgesic Action of Morphine

作者：Bujalska Zadrozny Magdalena^*; Duda Kamila

来源：Pharmacology, 2014, 93(3-4): 113-119.

DOI：10.1159/000358255

• Analgesia
• Diabetes
• Magnesium ions
• N-methyl-D-aspartate receptor
• Morphine
• Rats

As previously reported, magnesium ions (Mg2+) administered in relatively low doses markedly potentiated opioid analgesia in neuropathic pain, in which the effectiveness of opioids is limited. Considering that Mg2+ behaves like an N-methyl-D-aspartate receptor antagonist, the effect of this ion on the analgesic action of morphine was compared with that of MK-801. Acute pain was evoked by mechanical or thermal stimuli, whereas neuropathic hyperalgesia was induced by streptozotocin (STZ) administration. Magnesium sulphate (40 mg/kg i.p.) or MK-801 (0.05 mg/kg s.c.) administered alone did not modify the nociceptive threshold to acute stimuli or the streptozotocin hyperalgesia but significantly augmented the analgesic action of morphine (5 mg/kg i.p.). Furthermore, if these drugs (i.e. magnesium sulphate and MK-801) were applied concomitantly, a clear additive effect on the analgesic action of morphine occurred in both models of pain. Possible explanations of these observations are discussed.

• 出版日期2014