Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum

作者：Chai, Weiyun; Chen, Lu; Lian, Xiao-Yuan^*; Zhang, Zhizhen^*

来源：Planta Medica, 2018, 84(11): 786-794.

DOI：10.1055/s-0044-101038

• tripolinolate A
• Tripolium pannonicum
• Compositae
• anti-glioma
• apoptosis
• cell cycle arrest
• glioma metabolic enzymes

Tripolinolate A as a new bioactive phenolic ester was previously isolated from a halophyte of Tripolium pannonicum . However, the in vitro and in vivo anti-glioma effects and mechanism of tripolinolate A have not been investigated. This study has demonstrated that (1) tripolinolate A inhibited the proliferation of different glioma cells with IC (50) values of 7.97 to 14.02 mu M and had a significant inhibitory effect on the glioma growth in U87MG xenograft nude mice, (2) tripolinolate A induced apoptosis in glioma cells by downregulating the expressions of antiapoptotic proteins and arrested glioma cell cycle at the G (2) /M phase by reducing the expression levels of cell cycle regulators, and (3) tripolinolate A also remarkably reduced the expression levels of several glioma metabolic enzymes and transcription factors. All data together suggested that tripolinolate A had significant in vitro and in vivo anti-glioma effects and the regulation of multiple tumor-related regulators and transcription factors might be responsible for the activities of tripolinolate A against glioma.

• 出版日期2018-7
• 单位浙江大学