A new laccase-catalyzed domino process and its application to the efficient synthesis of 2-aryl-1H-benzimidazoles

作者：Leutbecher Heiko; Constantin Mihaela Anca; Mika Sabine; Conrad Juergen; Beifuss Uwe^*

来源：Tetrahedron Letters, 2011, 52(5): 605-608.

DOI：10.1016/j.tetlet.2010.11.145

• Laccase
• Aerobic oxidation
• Domino reactions
• N-Heterocycles

The laccase-catalyzed domino reaction of o-phenylenediamine and benzaldehydes with aerial oxygen as the oxidant exclusively yields 2-aryl-1H-benzimidazoles in good to very good yields. It is easy to perform under very mild reaction conditions.

• 出版日期2011-2-2