Aromatic Heterocycles as Activating Groups for Asymmetric Conjugate Addition Reactions. Enantioselective Copper-Catalyzed Reduction of 2-Alkenylheteroarenes

作者：Rupnicki Leszek; Saxena Aakarsh; Lam Hon Wai^*

来源：Journal of the American Chemical Society, 2009, 131(30): 10386-+.

DOI：10.1021/ja904365h

The versatility of chiral copper hydride catalysis has been demonstrated through development of highly enantioselective 1,4-reductions of 2-alkenytheteroarenes, substrates that have been rarely considered for asymmetric conjugate addition reactions. Both azoles and azines serve as efficient activating groups for this process.

• 出版日期2009-8-5