摘要
We evaluated the effect of buprenorphine, a mixed agonist for mu-opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors, in neuropathic rats, using the paw pressure test. Buprenorphine, administered i.p. at 50, but not 20 mu g/kg, exhibited naloxone-reversible analgesic activity in naive rats. In contrast, buprenorphine at 0.5 - 20 mu g/kg produced a naloxone-sensitive antihyperalgesic effect in the L5 spinal nerve injured neuropathic rats. Intrathecal injection of [N-Phe(1)]nociceptin(1-13)NH2, a NOP-receptor antagonist, reversed the effect of buprenorphine in neuropathic rats, but not in naive rats. Together, buprenorphine suppresses neuropathic hyperalgesia by activating NOP and opioid receptors, suggesting its therapeutic usefulness in treatment of neuropathic pain.
- 出版日期2013-5