An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines

作者：Martin Romy E; Polomska Marta E; Byrne Lindsay T; Stewart Scott G^*

来源：Tetrahedron Letters, 2011, 52(38): 4878-4881.

DOI：10.1016/j.tetlet.2011.07.047

• Indolizidines
• Intramolecular Tsuji-Trost reaction
• Allylation
• Pumiliotoxins

Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material L-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers.

• 出版日期2011-9-21