Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice

作者：Cahalan Stuart M; Gonzalez Cabrera Pedro J; Sarkisyan Gor; Nhan Nguyen; Schaeffer Marie Therese; Huang Liming; Yeager Adam; Clemons Bryan; Scott Fiona; Rosen Hugh^*

来源：Nature Chemical Biology, 2011, 7(5): 254-256.

DOI：10.1038/nchembio.547

Sphingosine 1-phosphate receptor 1 (S1P(1)) is critical for lymphocyte recirculation and is a clinical target for treatment of multiple sclerosis. By generating a short-duration S1P(1) agonist and mice in which fluorescently tagged S1P(1) replaces wild-type receptor, we elucidate physiological and agonist-perturbed changes in expression of S1P(1) at a subcellular level in vivo. We demonstrate differential downregulation of S1P(1) on lymphocytes and endothelia after agonist treatment.

• 出版日期2011-5