Systematic review of cost-effectiveness analyses of novel oral anticoagulants for stroke prevention in atrial fibrillation

作者：Ferreira Joao^*; Mirco Ana

来源：Revista Portuguesa de Cardiologia, 2015, 34(3): 179-191.

DOI：10.1016/j.repc.2014.08.008

• Novel oral anticoagulants
• Apixaban
• Dabigatran
• Edoxaban
• Rivaroxaban
• Cost-effectiveness
• Atrial fibrillation

Introduction and Objectives: Novel oral anticoagulants are emerging options for the prevention and treatment of thromboembolic diseases. They are increasingly used in clinical practice due to their simplicity of use and clinical benefits, but an important step is to evaluate their cost-effectiveness. The aim of the AFFORD study (A Review of Cost EFFectiveness of Novel ORal Anticoagulant Drugs) was to perform a systematic review of cost-effectiveness studies of novel oral anticoagulants for stroke prevention in non-valvular atrial fibrillation (AF).
Methods: A systematic review of the literature was conducted by searching the PubMed, Embase, Scopus, Cochrane and Web of Knowledge databases to identify all cost-effectiveness studies of novel oral anticoagulants for stroke prevention in AF.
Results: The search identified 27 studies, 18 with dabigatran, three with apixaban, two with rivaroxaban and four with at least two of these drugs. The incremental cost-effectiveness ratios were 30 405 +/- 16 101 euros per quality-adjusted life-year (QALY) for dabigatran 110 mg, 17 566 16 902 euros/QALY for dabigatran 150 mg, 8102 +/- 3252 euros/QALY for age-adjusted dabigatran, 11 897 +/- 3341 euros/QALY for apixaban and 17 960 +/- 12 005 euros/QALY for rivaroxaban.
Conclusion: The present systematic review demonstrates that novel oral anticoagulants are cost-effective for stroke prevention in AF.

• 出版日期2015-3