Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study

作者：Aubertin Leheudre Mylene^*; Anton Stephen; Beavers Daniel P; Manini Todd M; Fielding Roger; Newman Ann; Church Tim; Kritchevsky Stephen B; Conroy David; McDermott Mary M; Botoseneanu Anda; Hauser Michelle E; Pahor Marco

来源：Journal of the American Medical Directors Association, 2017, 18(4): 312-319.

DOI：10.1016/j.jamda.2016.10.001

• Muscle strength
• obesity
• metabolic syndrome
• aging

Objective: The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults.
Methods: A total of 1453 men and women (age >= 70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions.
Results: A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P <=.01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 +/- 12.9 and NDYN-O = 111.2 +/- 13.1) than in nonobese (NDYNNO = 93.1 +/- 10.7 and DYN-NO = 92.2 +/- 11.2, P <=.01); and higher in NDYN-O compared with DYN-O (P <=.008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 +/- 10.1 vs 67.7 +/- 9.7, P <=.001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P >.05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]).
Conclusion: Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.

• 出版日期2017-4-1