Design, Synthesis, and Antihyperlipidemic Evaluation of Novel 2-[1-(Substitutedphenyl)-4-oxo-azetidin-2-yl]-5,6-disubstitutedthieno[2, 3-d]pyrimidin-4(3H)-ones

作者：Arya Nikhilesh; Munde Manoj K; Dwivedi Jaya; Jagdale Archana Y; Jain Kishor S^*

来源：Archiv der Pharmazie, 2013, 346(8): 588-595.

DOI：10.1002/ardp.201300001

• Antihyperlipidemic
• Azetidinone
• Gewald

Novel thienopyrimidine derivatives of azetidinone possessing the combined features of the cholesterol absorption inhibitor drug ezetimibe and potential antihyperlipidemic 2-substitutedthienopyrimidin-4ones were synthesized and characterized by spectroscopic data and elemental analysis. These compounds were evaluated for their lipid-lowering activity in Wistar albino rats. Some of them showed significant lipid-lowering effects comparable to those of the standard drug, gemfibrozil, at the same dose levels.

• 出版日期2013-8