A formal synthesis to (+)-nephrosteranic acid from chiral nitroalkyl derivatives

作者：Barreto Cleber B Jr; Patrocinio Pereira Vera L

来源：Tetrahedron Letters, 2009, 50(46): 6389-6392.

DOI：10.1016/j.tetlet.2009.08.087

A concise and versatile formal synthesis to (+)-nephrosteranic acid was accomplished from a common nitroderivative 2 in a sequence of six steps. The adduct 2 was obtained via a highly syn-diastereoselective conjugate addition of 1-dodecyl nitronate ion to chiral enoate Z-5 (yield = 80%; de = 95%), derived from D-(+)-mannitol.

• 出版日期2009-11-18