Associations between transforming growth factor-β1 gene-509C/T and+915G/C polymorphisms and pneumoconiosis: a meta-analysis

作者：Li, Xiao; Zong, Qiang; Han, Fang^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(3): 5764-5772.

• Transforming growth factor-beta 1
• -509C/T
• +915G/C
• meta-analysis
• polymorphism

Transforming growth factor-beta 1 (TGF-beta 1) gene -509C/T and +915G/C polymorphisms has been reported to be associated with pneumoconiosis susceptibility. However, the relevant study results are still inconsistent. To further evaluate the impact of the TGF-beta 1 -509C/T and +915G/C polymorphisms on pneumoconiosis, we performed this meta-analysis. We performed a meta-analysis to analyze the association after searching the relevant studies through China National Knowledge Infrastructure (CNKI), PubMed and EMBASE databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the association. Totally, 10 studies involving 2,052 cases and 1,902 controls were retrieved in this meta-analysis. The results showed evidence for significant association between -509C/T, +915G/C polymorphisms and pneumoconiosis susceptibility. However, for -509C/T polymorphism, similar results were only found in coal workers' pneumoconiosis; +915G/C polymorphism merely increase the silicosis risk. This meta-analysis suggests that the TGF-beta 1 -509C/T and +915G/C polymorphisms are associated with pneumoconiosis. But they exerted different effects on different types of pneumoconiosis.

• 出版日期2016
• 单位北京大学; 天津医科大学; 滨州医学院