An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

作者：Hopkin Mark D; Baxendale Ian R; Ley Steven V^*

来源：Organic and Biomolecular Chemistry, 2013, 11(11): 1822-1839.

DOI：10.1039/c2ob27002a

A flow-based route to imatinib, the API of Gleevec, was developed and the general procedure then used to generate a number of analogues which were screened for biological activity against Abl1. The flow synthesis required minimal manual intervention and was achieved despite the poor solubility of many of the reaction components.

• 出版日期2013