The Effect of Triglyceride Concentration on Attainment of Lipid Targets in Patients with Diabetes

作者：Cartier Louis Jacques^*; Collins Charlene; Lagace Mathieu; Douville Pierre

来源：Canadian Journal of Diabetes, 2017, 41(4): 380-384.

DOI：10.1016/j.jcjd.2016.12.006

• diabetes
• glycated hemoglobin (A1C)
• lipid target
• triglycerides (TG)
• clinical practice guidelines

Objectives: To evaluate the effects of triglyceride (TG) and glycated hemoglobin (A1C) concentrations in the percentage of patients with diabetes who are within target (WT) for low-density lipoprotein-cholesterol (LDL-C), non-high-density lipoprotein-cholesterol (non-HDL-C) and apolipoprotein B (ApoB), as defined by the Canadian Lipid Guidelines, in a cohort of outpatients presenting at a 350-bed community hospital.
Methods: Laboratory samples from 1919 patients, 18 years or older, who had A1C levels of 6.5% or above were used. Fasting lipid profiles were retrieved, and ApoB was measured.
Results: We found no significant difference in the percentage of those WT for LDL-C as TG increased from normal to intermediate and high levels. For non-HDL-C, we saw a substantial decrease in the percentage of patients WT as TG levels increased from normal (61%) to intermediate (30.4%) and high levels (14.0%). ApoB showed a similar pattern to non-HDL-C: decreasing from normal (68.8%) to intermediate (40.7%) and high levels (21.0%). No significant difference was seen in the percentage of patients WT for the 3 lipid parameters studied with the increase in A1C levels.
Conclusions: As TG increases, we saw discordance in the percentage of patients WT for LDL-C in relation to non-HDL-C and ApoB. Alternative targets to LDL-C should preferentially be used when the TG concentration is elevated.

• 出版日期2017-8