Adjuvant chemoradiation after laparoscopically assisted vaginal radical hysterectomy (LARVH) in patients with cervical cancer Oncologic Outcome and Morbidity

作者：Gruen Arne; Musik Thabea; Koehler Christhardt; Fueller Juergen; Wendt Thomas; Stromberger Carmen; Budach Volker; Schneider Achim; Marnitz Simone^*

来源：Strahlentherapie und Onkologie, 2011, 187(6): 344-349.

DOI：10.1007/s00066-011-2197-7

• Cervical cancer
• Laparoscopically assisted radical vaginal hysterectomy (LARVH)
• (Chemo-)radiotherapy
• Toxicity

Compared to laparotomic surgery, laparoscopically assisted radical vaginal hysterectomy (LARVH) offers decreased blood loss during surgery and faster convalescence of the patient postoperatively, while at the same time delivering similar oncologic results. However, there is no data on outcome and toxicity of LARVH followed by (chemo)radiation.
A total of 55 patients (range 28-78 years) with cervical cancer on FIGO stages IB1-IIIA (Tables 1 and 2) with risk factors were submitted to either external beam radiotherapy alone [EBRT, n = 8 (14%), including paraaortic irradiation, n = 4 (2.2%); EBRT and brachytherapy (BT), n = 33 (60%); BT alone, n = 14 (25.5%)] or chemoradiation after LARVH.
At a median follow-up of 4.4 years, the 5-year disease-free survival (DFS) was 81.8% with 84.5% overall survival (OS). Acute grade 3 side effects were seen in 4 patients. These were mainly gastrointestinal (GI) and genitourinary (GU) symptoms. Grade 4 side effects were not observed.
With similar oncologic outcome data and mostly mild side effects, LARVH followed by (chemo)radiation is a valid alternative in the treatment of cervical cancer patients.

• 出版日期2011-6