A Review: Epigenetic Mechanism in Ochratoxin A Toxicity Studies

作者：Zhu Liye; Zhang Boyang; Dai Yaqi; Li Hongyu; Xu Wentao^*

来源：Toxins, 2017, 9(4): 113.

DOI：10.3390/toxins9040113

• Ochratoxin A
• epigenetic mechanism
• DNA methylation
• non-coding RNA
• histone modification

Ochratoxin A (OTA) is a natural contaminant that has displayed nephrotoxicity and hepatotoxicity in mammals. It contaminates a great variety of foodstuffs and threatens people's lives. The molecular mechanism of OTA-induced toxicity has been studied since 1965. Moreover, epigenetic mechanisms are also studied in OTA-induced toxicity. Additionally, the mode of OTA epigenetic research has been advanced in research hotspots. However, there is still no epigenetic study of OTA-induced toxicity. In this review, we discuss the relationship between these epigenetic mechanisms and OTA-induced toxicity. We found that studies on the epigenetic mechanisms of OTA-induced toxicity all chose the whole kidney or liver as the model, which cannot reveal the real change in DNA methylation or miRNAs or histone in the target sites of OTA. Our recommendations are as follows: (1) the specific target site of OTA should be detected by advanced technologies; and (2) competing endogenous RNAs (ceRNA) should be explored with OTA.

• 出版日期2017-4
• 单位中国农业大学