Body size and the risk of multiple sclerosis in Norway and Italy: The EnvIMS study

作者：Wesnes Kristin^*; Riise Trond; Casetta Ilaria; Drulovic Jelena; Granieri Enrico; Holmoy Trygve; Kampman Margitta T; Landtblom Anne Marie; Lauer Klaus; Lossius Andreas; Magalhaes Sandra; Pekmezovic Tatjana; Bjornevik Kjetil; Wolfson Christina; Pugliatti Maura; Myhr Kjell Morten

来源：Multiple Sclerosis, 2015, 21(4): 388-395.

DOI：10.1177/1352458514546785

• Multiple sclerosis
• body size
• obesity
• epidemiology
• vitamin D
• case control studies
• body mass index

Background: Obesity may be a risk factor for developing multiple sclerosis (MS).
Objective: We examined if body size influences the risk of MS in a population-based, case control study.
Methods: A total of 953 cases and 1717 controls from Norway and 707 cases and 1333 controls from Italy reported their body size by choosing a silhouette 1 to 9 (largest) every fifth year from age 5 to 30 and at time of study. The body size-related MS risk was defined by odds ratios (ORs) in logistic regression analyses adjusting for age, smoking and outdoor activity.
Results: In Norway a large body size (silhouettes 6-9) compared to silhouette 3 increased the risk of MS, especially at age 25 (OR 2.21; 95% CI 1.09-4.46 for men and OR 1.43; 95% CI 0.90-2.27 for women). When comparing silhouette 9 to 1, we found a significant dose-response from age 10 until age 30 peaking at age 25 (sex-adjusted OR 2.83; 95% CI 1.68-4.78). The association was present for at least 15 years prior to disease onset. No significant associations were found in Italy.
Conclusions: Obesity from childhood until young adulthood is a likely risk factor for MS with a seemingly stronger effect in Norway than in Italy.

• 出版日期2015-4
• 单位McGill