Does Meniere's Disease Really Increase Traveling Wave Velocity of the Basilar Membrane? Estimation with Frequency-Specific Electrocochleography

作者：Sen Deniz; Satar Bulent^*; Yetiser Sertac

来源：Journal of International Advanced Otology, 2009, 5(2): 177-186.

Objective: Aim of the study was to compare Action Potential latency difference (as a measure of traveling wave velocity-TWV) using electrocochleography (ECoG) in Meniere patients, non-Meniere cochlear hearing loss patients and control subjects.
Materials and Methods: This prospective study included three groups, 38 patients with Meniere's disease (41 ears), 30 patients with cochlear hearing loss other than Meniere's disease (40 ears) and 25 healthy subjects (40 ears). Tympanic membrane ECoG (click and tone-burst evoked) and caloric test were performed. Forty one ears with Meniere's disease were categorized into definite (28 ears) and probable Meniere patients (13 ears) based on recommendation of the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology-Head and Neck Surgery. Summation potential (SP) / action potential (AP) ratio and AP latency difference for 0.5 kHz and 2 kHz were measured in click and tone-burst evoked ECoG. In caloric test, unilateral weakness was sought. The patients were then further stratified based on abnormal SP/AP ratio and presence of UW. AP latency difference was compared among the groups and subgroups (based on SP/AP ratio and presence of UW).
Results: Median AP latency differences were 0.14, 0.25, 0.19 and 0.23 ms in probable and definite Meniere groups, non-Meniere group and control subjects, respectively. There was significant differences in TWV between definite Meniere group and control group and also between probable Meniere and definite Meniere groups (p's<0.05). When including cases with abnormal SP/AP ratio, AP latency difference were 0.06, 0.25, 0.21 and 0.13 ms. AP latency difference were 0.12 and 0.23 ms in probable and definite Meniere groups with UW.
Conclusions: There was significant difference in TWV in probable and definite Meniere groups. This can be explained with adhesion or fibrosis involved with the basilar membrane hampering its appropriate movement in definite Meniere patients. Including cases with abnormal SP/AP ratio better distinguished probable and definite Meniere groups from control group. Presence of UW only helps better separation between probable Meniere group and control group.

• 出版日期2009
• 单位中国人民解放军军事医学科学院