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摘要
A novel tandem Betti/Ullmann/oxidation reaction was used for synthesis of new oxazepine derivatives containing kojic acid. This protocol includes a three-component Betti reaction of 2-naphthol, 2-haloanilines and kojic aldehyde followed by copper-mediated intramolecular Ullmann C-O coupling reaction and subsequently aerobic oxidation. This method provides a new and useful strategy for the construction of heterocycles. Also novel Betti bases based on kojic acid derivatives have been synthesized. In this regard, boric acid functionalized silica supported nanoparticle have been designed, synthesized and used as a highly efficient, environmentally benign and recyclable heterogeneous magnetic nanocatalyst for the direct synthesis of desired Betti bases under solvent free conditions. A novel tandem Betti/Ullmann/oxidation reaction was introduced for synthesis of new oxazepine derivatives. This method provides a new and useful strategy for the construction of heterocycles. In this regard, @-boric acid nanoparticles have been synthesized and used for the synthesis of desired novel Betti bases based on kojic acid derivatives.
- 出版日期2017-9
