Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase

作者：al Rashida Mariya^*; Ashraf Muhammad; Hussain Bushra; Nagra Saeed Ahmad; Abbas Ghulam

来源：Bioorganic & Medicinal Chemistry, 2011, 19(11): 3367-3371.

DOI：10.1016/j.bmc.2011.04.040

• Carbonic anhydrase
• Carbonic anhydrase inhibitors
• Formylchromones
• Sulfonamides

Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-aminobenzenesulfonamide. Bovine carbonic anhydrase (bCA) inhibitory activity of these newly synthesized compounds was determined. All compounds were active and possessed excellent bCA inhibitory activities with IC(50) values ranged between 4.31 +/- 0.001 and 29.12 +/- 0.008 mu mol. Compounds derived from 6-fluoro-3-formylchromones were the most active.

• 出版日期2011-6-1