Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances

作者：Purtov K V^*; Petunin A I; Burov A E; Puzyr A P; Bondar V S

来源：Nanoscale Research Letters, 2010, 5(3): 631-636.

DOI：10.1007/s11671-010-9526-0

• Nanodiamonds
• Ligand
• Protein immobilization
• Nanocarrier
• Targeted delivery

Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgG(I125) and RAM-nanodiamond-BSA(I125) complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSA(I125) complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibody-antigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo.

• 出版日期2010-3