Antimony(III) chloride-catalysed Biginelli reaction: a versatile method for the synthesis of dihydropyrimidinones through a different reaction mechanism

作者：Cepanec Ivica^*; Litvic Mladen; Filipan Litvic Mirela; Grungold Ivana

来源：Tetrahedron, 2007, 63(48): 11822-11827.

DOI：10.1016/j.tet.2007.09.045

Antimony(III) chloride (20 mol %) in refluxing acetonitrile efficiently catalyses the synthesis of dihydropyrimidinones (50-90% yields) by the Biginelli reaction of aromatic aldehydes, acetoacetate esters and urea. This reaction proceeds through 3-ureido-crotonates followed by cyclisation with an aromatic aldehyde to the dihydropyrimidinone.

• 出版日期2007-11-26