Newly characterized crystal structures: further insights into the architecture of GPCRs

作者：Tan, Binghe; Liu, Mingyao^*

来源：Science China Life Sciences, 2018, 61(5): 593-596.

DOI：10.1007/s11427-017-9159-6

• PROTEIN-COUPLED RECEPTORS

<正>G protein-coupled receptors (GPCRs), also known as seven-transmembrane (7TM) receptors, are crucial components of numerous cellular signaling cascades. There are about 900 GPCRs in the human genome, making GPCRs the largest family of cell-surface receptors (Lappano and Maggiolini, 2011). GPCRs are classified into six classes based on sequence homology and functional similarity: rhodopsin-like receptors (Class A ), the secretin receptor family (Class B), metabotropic glutamate receptors (Class C), fungal mating pheromone receptors (Class D),

• 出版日期2018-5
• 单位华东师范大学