The relation between glycemic control and HDL-C in type 2 diabetes: a preliminary step forward?

作者：Barbarossa G; Renzi A; D'Erasmo L; Gallo A; Grieco E; Rossetti M; Carnovale A; Santilli M; Mandosi E; Coletta P; Pergolini D; Morano S; Maranghi M^*

来源：Diabetes Research and Clinical Practice, 2014, 104(1): E26-E28.

DOI：10.1016/j.diabres.2013.12.061

• HDL-cholesterol
• Glycated haemoglobin
• Type 2 diabetes
• Glycemic control

Low high-density lipoprotein cholesterol (HDL-C) levels are associated with cardiovascular (CV) disease in type 2 diabetes (T2D). Unfortunately available drugs to increase HDL-C have failed to demonstrate a reduction in CV risk. We assessed the effect of improving glycemic control on HDL-C levels. A 6-month intervention resulted in significant improvement in HbA1c but not in HDL-C levels. However, when considering the subgroup of subjects with low levels of HDL-C at baseline, we found a significant and inverse relation between improvement in HbA1c and HDL-C levels.

• 出版日期2014-4