Massive Carbamazepine Overdose: Any Role of Hemodialysis?: Case Report

作者：Ozsarac Murat^*; Sever Mustafa; Gokova Sema; Ersel Murat; Sezis Meltem

来源：Turkiye Klinikleri Tip Bilimleri Dergisi, 2011, 31(3): 702-705.

DOI：10.5336/medsci.2009-13386

• Anticonvulsants
• poisoning
• carbamazepine
• renal dialysis

Massive carbamazepine (CBZ) overdose is associated with life-threatening hemodynamic complications that present challenges for clinicians. We describe the highest-reported dose of CBZ intoxication in a patient who survived and discuss early hemodialysis option in a CBZ-poisoned patient. Although hemodialysis is reported to increase the elimination of CBZ despite its partiall effectiveness due to the poor water-solubility of CBZ, massive CBZ overdose can induce an acute renal failure and renal function should be monitored closely, and the data obtained from this case that standard low-flux HD might be used and is effective in the management of acute CBZ overdose in patients with associated electrolyte disorders and acute renal failure.

• 出版日期2011-6