科研之友
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摘要
Peroxisome proliferator-activated receptor-gamma ( PPAR gamma) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays an important role in the control of gene expression linked to a variety of physiological processes, including cancer. Ligands for PPAR. include naturally occurring fatty acids and the thiazolidinedione class of antidiabetic drugs. Activation of PPAR gamma in a variety of cancer cells leads to inhibition of growth, decreased invasiveness, reduced production of proinflammatory cytokines, and promotion of a more differentiated phenotype. However, systemic activation of PPAR gamma has been reported to be protumorigenic in some in vitro systems and in vivo models. Here, we review the available data that implicate PPAR gamma in lung carcinogenesis and highlight the challenges of targeting PPAR gamma in lung cancer treatments.
- 出版日期2012
