Nano-ranged calix[4]arene tetracarboxylic acid catalyzed expeditious protocol for spiro[dihydropyridine-oxindoles] synthesis

作者：Sarkar Piyali; Mukhopadhyay Chhanda

来源：Tetrahedron Letters, 2016, 57(38): 4306-4310.

DOI：10.1016/j.tetlet.2016.08.037

• Spiro[dihydropyridine-oxindoles]
• Calix[4]arene tetracarboxylic acid
• Water-medium
• ortho-H involvement
• Nano-ranged organocatalyst

Calix[4]arene tetracarboxylic acid has been successfully established as the nanoranged organocatalyst for the synthesis of spiro[dihydropyridine-oxindoles]. Here we report a sustainable protocol for the synthesis of spiro[dihydropyridine-oxindoles], an Mannich type multi-component reaction involving the ortho-H of activated as well as un-activated aniline derivatives. A library of new spiro derivatives have been synthesized in very high yields in eco-friendly solvent water in one-pot multicomponent fashion.

• 出版日期2016-9-21