Anti-Inflammatory Effect of Emodin via Attenuation of NLRP3 Inflammasome Activation

作者：Han Ji Won; Shim Do Wan; Shin Woo Young; Heo Kang Hyuk; Kwak Su Bin; Sim Eun Jeong; Jeong Jae Hyun; Kang Tae Bong; Lee Kwang Ho^*

来源：International Journal of Molecular Sciences, 2015, 16(4): 8102-8109.

DOI：10.3390/ijms16048102

• emodin
• interleukin (IL)-1
• NLRP3 inflammasome
• sepsis

Emodin, an active constituent of oriental herbs, is widely used to treat allergy, inflammation, and other symptoms. This study provides the scientific basis for the anti-inflammasome effects of emodin on both in vitro and in vivo experimental models. Bone marrow-derived macrophages were used to study the effects of emodin on inflammasome activation by using inflammasome inducers such as ATP, nigericin, and silica crystals. The lipopolysaccharide (LPS)-induced endotoxin shock model was employed to study the effect of emodin on in vivo efficacy. Emodin treatment attenuated interleukin (IL)-1 secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals. Further, emodin ameliorated the severity of NLRP3 inflammasome-mediated symptoms in LPS-induced endotoxin mouse models. This study is the first to reveal mechanism-based evidence, especially with respect to regulation of inflammasome activation, substantiating traditional claims of emodin in the treatment of inflammation-related disorders.

• 出版日期2015-4