Convenient synthesis of 2-amino-3-(arylthio)indoles via the Rh-catalyzed reaction of 3-diazoindol-2-imines with thioesters

作者：Ma, Fanghui; Qian, Jing; Lu, Ping^*; Wang, Yanguang^*

来源：Organic and Biomolecular Chemistry, 2018, 16(3): 439-443.

DOI：10.1039/c7ob02597a

• EFFICIENT SULFENYLATION
• ARYLSULFONYL CHLORIDES
• MILD CONDITIONS
• INDOLES
• IODINE
• 3-DIAZOINDOLIN-2-IMINES
• INHIBITORS
• 3-SULFENYLATION
• SULFUR
• ACIDS

2-Amino-3-(arylthio)indoles were conveniently synthesized via the Rh(II)-catalyzed C-S/N-C coupling reaction between 3-diazoindol-2-imines and thioesters. The products could be further oxidized to 2-amino-3-(arylsulfonyl)indoles by m-chloroperbenzoic acid and the N-sulfonyl group could be easily removed by reduction with SmI2.

• 出版日期2018-1-21
• 单位浙江大学