Different clinical effects upon separate inhibition of coexisting EGFR and PI3KCA mutations in a lung adenocarcinoma patient

作者：Tiseo Marcello^*; Bersanelli Melissa; Perrone Federica; Tamborini Elena; Settanni Giulio; Busico Adele; Rossi Giulio; Ardizzoni Andrea; Pelosi Giuseppe

来源：Lung Cancer, 2015, 87(2): 204-206.

DOI：10.1016/j.lungcan.2014.12.008

• NSCLC
• EGFR
• PI3KCA
• Gene mutations
• Erlotinib
• PI3K inhibitor

We present a very interesting case of lung adenocarcinoma carrying an uncommon EGFR exon 19 insertion with concomitant PIK3CA mutation showing dramatic and persisting improvement upon erlotinib therapy, after progression during PI3K inhibitor.

• 出版日期2015-2