AbobotulinumtoxinA for Reduction of Glabellar Lines in Patients with Skin of Color: Post Hoc Analysis of Pooled Clinical Trial Data

作者：Taylor Susan C^*; Callender Valerie D; Albright Craig D; Coleman Jeffrey; Axford Gatley Robert A; Lin Xiaoming

来源：Dermatologic Surgery, 2012, 38(11): 1804-1811.

DOI：10.1111/j.1524-4725.2012.02551.x

BACKGROUND A paucity of research exists on the safety and efficacy of aesthetic medicine products in patients with skin of color (SOC).
OBJECTIVE To compare the effectiveness and tolerability of abobotulinumtoxinA (BoNTA-ABO) for glabellar lines in a subpopulation of patients with SOC with that in white patients.
MATERIALS AND METHODS This post hoc analysis considered pooled safety data from six clinical trials from which were derived a safety population (n = 1,869 white, n = 472 SOC), an efficacy population for a comparison of fixed-dose BoNTA-ABO 50 U in white patients (n = 216) and patients with SOC (n = 117), and an efficacy population for a comparison of BoNTA-ABO adjusted to muscle mass in white (n = 555) and patients with SOC (n = 160).
RESULTS Adverse event rates were similar in white patients and patients with SOC. Onset of effect was similar in patients with SOC and white patients, but the response rate 30 days after treatment was greater in patients with SOC than in white patients.
CONCLUSION Tolerability and effectiveness of treatment BoNTA-ABO for glabellar lines was similar in patients with SOC and white patients.

• 出版日期2012-11