A study of dysphagia symptoms and esophageal body function in children undergoing anti-reflux surgery

作者：Omari T^*; Connor F; McCall L; Ferris L; Ellison S; Hanson B; Abu Assi R; Khurana S; Moore D

来源：United European Gastroenterology Journal, 2018, 6(6): 819-829.

DOI：10.1177/2050640618764936

• Gastroesophageal reflux
• fundoplication
• dysphagia
• diagnosis

Background: The role of high-resolution esophageal impedance manometry (HRIM) for establishing risk for dysphagia after anti-reflux surgery is unclear. We conducted a prospective study of children with primary gastroesophageal reflux (GER) disease, for whom symptoms of dysphagia were determined pre-operatively and then post-operatively and we examined for features that may predict post-operative dysphagia.
Methods: Thirteen children (aged 6.8-15.5 years) undergoing work-up prior to 360 degrees Nissen fundoplication were included in the study. A dysphagia score assessed symptoms at pre-operative study and post-operatively (mean 1.4 years). A HRIM procedure recorded 5-ml liquid, 5-ml viscous and 2-cm solid boluses. We assessed esophageal motility, esophago-gastric junction (EGJ) morphology, EGJ contractility and pressure-flow variables indicative of bolus distension pressures and bolus clearance pressures. A composite pressure-flow index score was also derived.
Results: Pre-operative pressure-flow index was positively correlated with post-operative dysphagia score (viscous bolus r= 0.771, p< 0.005). Of three variables that comprise the pressure-flow index, the ramp pressure measured during bolus clearance was the main driver of the effect seen (viscous bolus r= 0.819, p < 0.005).
Conclusions: In order to mitigate symptoms in relation to anti-reflux surgery, dysphagia symptoms and esophageal function need to be pre-operatively assessed. In patients with normal motility, an elevated pressure-flow index may predict post-operative dysphagia.

• 出版日期2018-7