Umbilical Artery Doppler Study as a Predictive Marker of Perinatal Outcome in Preterm Small for Gestational Age Infants

作者：Byun Young Ji; Kim Haeng Soo^*; Yang Jeong In; Kim Joon Hyung; Kim Ho Yeon; Chang Suk Joon

来源：Yonsei Medical Journal, 2009, 50(1): 39-44.

DOI：10.3349/ymj.2009.50.1.39

• Preterm small for gestational age infant
• umbilical artery Doppler velocimetry
• perinatal outcome

Purpose: To evaluate the merit of umbilical artery Doppler study as a predictive marker of perinatal outcome in preterm small for gestational age (SGA) infants. Materials and Methods: A total of 218 patients at 27-36 weeks of gestational age (GA) who received antenatal umbilical artery Doppler velocimetry and delivered singleton infants with SGA. The ratio of peak-systolic to end-diastolic blood flow velocities (S/D) in the umbilical artery was measured in each patient. The patients were divided into 3 groups: the normal group with S/D ratios of less than 95th percentile (n=134), elevated S/D ratio group of 95th or more percentile (n=41), and those with absent/reversed end diastolic flow (n=43). Maternal characteristics and neonatal outcomes of these groups were comparatively analyzed. Results: The gestational age (GA) at the time of diagnosis of SGA, the mean GA at delivery, and the mean birth weight showed statistically significant difference among three groups (p<0.001). Also, poor perinatal outcome was significantly increased in infants with abnormal S/D ratio(13.4%vs. 31.7%vs. 67.4%, p<0.001). Multivariate logistic regression analysis revealed umbilical artery Doppler Study as a significant independent factor for prediction of poor perinatal outcome (odds ratio: 3.7, 95% confidence interval 1.4-9.5, p=0.007). Conclusion: Antenatal umbilical artery Doppler velocimetry is shown as a significantly efficient marker in predicting perinatal outcome in preterm SGA infants.

• 出版日期2009-2-28