A two-step synthesis of the bioprotective agent JP4-039 from N-Boc-L-leucinal

作者：Bernardim Barbara; Burtoloso Antonio C B^*

来源：Tetrahedron, 2014, 70(20): 3291-3296.

DOI：10.1016/j.tet.2013.10.059

• Bioprotective agents
• L-Leucine
• Unsaturated diazoketones
• Wolff rearrangement
• Diazophosphonates

An expedited synthesis of the bioprotective agent JP4-039 is described from N-Boc-L-leucinal in 50% overall yield. The synthesis involves the use of an alpha,beta-unsaturated diazoketone as the key intermediate, followed by a photochemical Wolff rearrangement in the presence of 4-amino-TEMPO (4-AT).

• 出版日期2014-5-20