Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors

作者：Mittapalli Gopi Kumar; Jackson Andrew; Zhao Fang; Lee Haekyung; Chow Stephine; McKelvy Jeffrey; Wong Staal Flossie^*; Macdonald James E

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(22): 6852-6855.

DOI：10.1016/j.bmcl.2011.09.019

• Hepatitis C Virus
• Entry inhibitors
• Tetrahydrocarbazoles
• HCVcc
• Pharmacokinetics

Novel, highly potent small molecule HCV entry inhibitors are reported. The SAR exploration of a hit molecule identified from screening of a compound library led to the identification of highly potent compounds with IC50 values of <5 nM in the tissue culture HCV infectious assay.

• 出版日期2011-11-15