Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis

作者：Rohatgi Soma; Nakouzi Antonio; Carreno Leandro J; Slosar Cheah Magdalena; Kuniholm Mark H; Wang Tao; Pappas Peter G; Pirofski Liise anne^*

来源：Open Forum Infectious Diseases, 2018, 5(1): UNSP ofx255.

DOI：10.1093/ofid/ofx255

• antibody immunity
• B cell subsets
• Cryptococcus neoformans
• HIV-associated cryptococcosis
• memory B cells

The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.

• 出版日期2018-1