A New Water-Soluble Branched Poly(ethylene imine) Derivative Having Hydrolyzable Imidazolidine Moieties and Its Application to Long-Lasting Release of Aldehyde

作者：Morinaga Hisatoyo; Morikawa Hiroshi; Sudo Atsushi; Endo Takeshi^*

来源：Journal of Polymer Science Part A: Polymer Chemistry , 2010, 48(20): 4529-4536.

DOI：10.1002/pola.24244

• amphiphiles
• branched poly(ethylene imine)
• imidazolidine rings
• stimuli-sensitive polymers
• water-soluble polymers

A new water-soluble poly(ethylene imine)-derivative having imidazolidine moieties was developed. With using branched poly(ethylene imine) (BPEI) as a precursor, it was modified by Michael addition reaction of its primary amino group to an acrylate having poly(ethylene glycol) (PEG) chain. The modified BPEI was reacted with octanal to give the corresponding BPEI derivative having octanal-derived imidazolidine moieties. The obtained polymer inherited the high hydrophilicity of the attached PEG chains to allow hydrolysis of the imidazolidine moieties under homogeneous conditions in aqueous media, leading to long-lasting release of octanal.

• 出版日期2010-9-15