DDQ-mediated oxidation of sp(3) C-H bond for the direct synthesis of vicinal tricarbonyl compounds

作者：Wang, Zheng-Lin; An, Xing-Lan; Ge, Li-Shi; Jin, Jing-Hai; Luo, Xiaoyan^*; Deng, Wei-Ping

来源：Tetrahedron, 2014, 70(24): 3788-3792.

DOI：10.1016/j.tet.2014.04.021

• Vicinal tricarbonyl compounds
• DDQ
• TEMPO

A facile and direct synthetic method was developed for the construction of vicinal tricarbonyl compounds (VTCs) in moderate to excellent yields (46-92%), by treating the readily available 1,3-dicarbonyl compounds with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The reaction pathway involves the DDQ-mediated oxidative activation of sp(3) C

• 出版日期2014-6-17
• 单位华东理工大学