An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women

作者：Wu, Bin^*; Huang, Jingshan; Zhang, Lihua; Kasukurthi, Mohan Vamsi; Huang, Fangwan; Bian, Jiang; Fukuo, Keisuke; Kazumi, Tsutomu

来源：Methods, 2018, 145: 60-66.

DOI：10.1016/j.ymeth.2018.04.016

• C-reactive protein
• Adipocytokines
• Inflammation marker
• microRNA
• Bio-ontology
• Semantic search

Prior research has indicated that as an important biomarker of chronic low-grade inflammation, high-sensitivity C-reactive protein (hs-CRP) can play important roles on the onset of metabolic syndrome and cardiovascular diseases (CVD). We conducted an integrative approach, which combines biological wet-lab experiments, statistical analysis, and semantics-oriented bioinformatics & computational analysis, to investigate the association among hs-CRP, body fat mass (FM) distribution, and other cardiometabolic risk factors in young healthy women. Research outcomes in this study resulted in two novel discoveries. Discovery 1: There are four primary determinants for hs CRP, i.e., central/abdominal FM (a.k.a. trunk FM) accumulation, leptin, high density lipoprotein cholesterol (HDL-C), and plasminogen activator inhibitior-1 (PAI-1). Discovery 2: Chronic inflammation may involve in adipocyte-cytokine interaction underlying the metabolic derangement in healthy young women.

• 出版日期2018-8-1
• 单位昆明医科大学; 山东省科学院; 福州大学