Ammonium chloride-catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions

作者：Shaabani A^*; Bazgir A; Teimouri F

来源：Tetrahedron Letters, 2003, 44(4): 857-859.

DOI：10.1016/S0040-4039(02)02612-6

• Biginelli reaction
• dihydropyrimidinones
• ammonium chloride
• one-pot condensation
• solvent-free

Ammonium chloride as a very inexpensive and readily available reagent, and efficiently catalyzes one-pot, three component, Biginelli condensation reactions of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones in high yields at 100degreesC.

• 出版日期2003-1-20