Emerging mechanisms of T-tubule remodelling in heart failure

作者：Guo Ang; Zhang Caimei; Wei Sheng; Chen Biyi; Song Long Sheng^*

来源：Cardiovascular Research, 2013, 98(2): 204-215.

DOI：10.1093/cvr/cvt020

• T-tubules
• Excitation-contraction coupling
• Calcium
• Heart failure
• Junctophilin-2

Cardiac excitationcontraction coupling occurs primarily at the sites of transverse (T)-tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the instantaneous excitation and synchronous activation of nearly all Ca-2 release sites throughout the large ventricular myocyte. Because of the critical roles played by T-tubules and the array of channels and transporters localized to the T-tubule membrane network, T-tubule architecture has recently become an area of considerable research interest in the cardiovascular field. This review will focus on the current knowledge regarding normal T-tubule structure and function in the heart, T-tubule remodelling in the transition from compensated hypertrophy to heart failure, and the impact of T-tubule remodelling on myocyte Ca-2 handling function. In the last section, we discuss the molecular mechanisms underlying T-tubule remodelling in heart disease.

• 出版日期2013-5-1