A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio

作者：Tan, Zihui; Zhang, Man; Han, Qiang; Wen, Jing; Luo, Kongjia; Lin, Peng; Zhang, Lanjun; Yang, Hong; Fu, Jianhua^*

来源：Journal of Cancer, 2017, 8(6): 1025-1029.

DOI：10.7150/jca.16491

• esophageal squamous cell carcinoma
• blood tool
• fibrinogen
• albumin

Background: Coagulation and nutrition play important roles in cancer progression. We aim to investigate the impact of the fibrinogen/albumin ratio(FAR) in esophageal squamous cell carcinoma (ESCC) patients.
Methods: We retrospectively analyzed 1135 patients with radical esophagectomy for ESCC from January 2008 to December 2010 in our center. X-tile software was used to determine the optimal cutoff levels for these biomarkers.
Results: The optimal cutoff value was 0.08 for the FAR by the X-tile software. The FAR was statistically significantly associated with age(p=0.003), sex(p=0.030), tumor length (p=0.043), pT status(p<0.001) and pN status(p<0.001). Pearson's correlation indicated that the FAR were positively associated with the serum C-reactive protein (CRP) (r=0.583, p<0.001), and the NLR ( r=0.316, p<0.001). Multivariate analysis indicated that age, tumor grade, pT status, pN status and preoperative FAR were independent prognostic factors in patients with ESCC.
Conclusions: Preoperative FAR was an independent prognostic factor in ESCC patients. Lower FAR may improve OS of ESCC patients.

• 出版日期2017
• 单位中山大学; 华南肿瘤学国家重点实验室