Approaches to the study of inflammatory gene haplotypes and susceptibility to cardiac, vascular and pulmonary diseases

作者：Daley D^*; Burkett K

来源：Current Opinion in Molecular Therapeutics, 2005, 7(3): 226-233.

• association
• haplotype blocks
• haplotypes
• single
• nucleotide polymorphisms

Haplotype association methods are increasingly being used in the study of complex diseases to better understand and correlate genetic polymorphisms with cardiovascular and pulmonary disease phenotypes and drug responses. Understanding of the human genome is rapidly expanding, how this knowledge is impacting the determination of haplotypes and how they can be utilized in the study of complex diseases is reviewed. Applied and methodological fields are discussed and examples of how haplotypes are used to study complex diseases in this modern era are provided.

• 出版日期2005-6